城市部分环境监测因子中铅含量的测定及与人体健康潜在关系的探讨

应用石墨炉原子吸收法测定了饮用水、地表水、酸雨、总悬浮颗粒物中铅的含量,并比较了饮用水源中可溶性铅与总铅的含量差别,探讨了以上各环境监因子中不同浓度水平的铅与人体健康的潜在关系。     

微量稀土元素的药效及保健作用

根据国内外微量稀土元素在医药方面应用的研究,介绍了稀土元素的一系列特殊的药效及保健作用。稀土元素可广泛用于治疗烧伤,炎症,皮肤病,血栓病等。     

高速列车服役模拟建模与计算方法研究

高速铁路的出现, 使得轮轨交通技术达到更高的层次.速度提升不仅对列车的牵引动力与动力学性能提出更高要求. 而且,列车与线路、气流等运行环境的耦合作用加剧,并直接影响到了列车的运行品质和安全性. 在高速列车发展初期,研究关注的是如何保证高速列车能高速、平稳和安全运行. 随着运行速度的提高,系统间耦合加强, 服役模拟也越来越受到重视. 而今天,高速列车的服役模拟、健康管理与故障预警成为研究热点,掌握系统全局动态行为、了解微观局部振动是车辆系统动力学研究的方向.本文以高速列车服役模拟为需求, 提出基于循环变量法的长编组列车建模与计算方法,实现任意列车编组的仿真, 得到不同编组位置车辆的服役状态;提出滑移窗口的轨道建模与车线耦合计算方法,得到列车在任意长线路上运行的服役状态; 提出基于时变参数的长期服役计算方法,实现列车在不同服役状态与服役时间的服役模拟. 因此, 基于本文提出的模拟方法,能够实现列车在不同寿命阶段的服役模拟, 而且还可以应用于高速磁浮列车,甚至未来超高速真空管道磁浮列车.      

基于不完备频响函数的结构损伤统计识别研究

基于不完备频响函数数据,结合概率统计方法,提出了一种能同时考虑模型参数不确定性和测试噪声影响的结构损伤统计识别方法。首先,基于频响函数某一行向量在不同频率下的幅值数据,利用矩阵拉直运算建立了关于损伤系数的确定性识别方程。其次,假设模型参数误差和测试噪声为零均值的高斯随机变量,根据摄动理论,推导了损伤后结构刚度参数的前二阶矩。随后,利用结构损伤前后的概率分布得到了结构损伤存在概率。最后,通过一个平面桁架结构模型验证了本文方法的有效性。数值算例的研究结果表明,损伤单元的损伤存在概率远大于非损伤单元;测试噪声对识别结果的影响比模型参数不确定性的影响更为显著。     

西藏林芝地区城镇居民消费支出的G(1,1)模型预测及其影响因素的关联度分析

利用2006—2012年林芝地区城镇居民人均生活消费支出数据为研究对象,应用灰色系统理论建立了林芝地区城镇居民消费的G(1,1)预测模型,对其未来几年的人均生活消费进行预测,分析得出:在未来五年中林芝地区城镇居民人均生活消费支出呈现攀升的态势,平均年增长率预计达到7.93%.并运用灰色关联分析方法对影响林芝地区城镇居民消费支出的主要因素进行系统分析,确定了各因素相对于消费支出的关联程度.     

A column generation approach for solving the patient admission scheduling problem

This paper addresses the Patient Admission Scheduling (PAS) problem. The PAS problem entails assigning elective patients to beds, while satisfying a number of hard constraints and as many soft constraints as is possible, and arises at all planning levels for hospital management. There exist a few, different variants of this problem. In this paper we consider one such variant and propose an optimization-based heuristic building on branch-and-bound, column generation, and dynamic constraint aggregation to solve it. We achieve tighter lower bounds than previously reported in the literature and, in addition, we are able to produce new best known solutions for five out of twelve instances from a publicly available repository.     

Using phase-type models to cost stroke patient care across health,social and community services

Stroke disease places a heavy burden on society, incurring long periods of time in hospital and community care, and associated costs. Also stroke is a highly complex disease with diverse outcomes and multiple strategies for therapy and care. Previously a modeling framework has been developed which clusters patients into classes with respect to their length of stay (LOS) in hospital. Phase-type models were then used to describe patient flows for each cluster. Also multiple outcomes, such as discharge to normal residence, nursing home, or death can be permitted. We here add costs to this model and obtain the Moment Generating Function for the total cost of a system consisting of multiple transient phase-type classes with multiple absorbing states. This system represents different classes of patients in different hospital and community services states. Based on stroke patients’ data from the Belfast City Hospital, various scenarios are explored with a focus on comparing the cost of thrombolysis treatment under different regimes. The overall modeling framework characterizes the behavior of stroke patient populations, with a focus on integrated system-wide costing and planning, encompassing hospital and community services. Within this general framework we have developed models which take account of patient heterogeneity and multiple care options. Such complex strategies depend crucially on developing a deep engagement with the health care professionals and underpinning the models with detailed patient-specific data.     

Nanoparticulate materials and regulatory policy in Europe: An analysis of stakeholder perspectives

The novel properties of nanoparticulate materials (NPM) and the rapid development of NPM based products have raised many unanswered questions and concerns by different stakeholders over its consequences for the environment and human health. These concerns have led to an increasing discussion in both the US and Europe about possible regulatory policies for NPM. In this article a comparative study of stakeholders’ perceptions on regulatory policy issues with NPM in Europe is presented. It was found that industry wants to regulate this area if the scientific evidence demonstrates that NPM are harmful, but also that the regulatory bodies do not find it necessary at this point of time to regulate until scientific evidence demonstrates that NPM are harmful. This research therefore shows that there will most likely not be any regulatory interventions until there is an established and convincing scientific knowledge base demonstrating that NPM can be hazardous. It is furthermore discussed in this article the different roles and responsibilities of the stakeholders in financing the research required to establish the necessary level of fundamental scientific evidence. It was also found that the activity of the regulatory bodies on this issue differ between the European countries.     

灰关联模式评估模型在大学生体质健康水平综合评价中的应用

针对在大学生体质健康水平评价过程中指标权重确定、评价标准区分度等问题,讨论了单层和多层灰关联模式评估模型,并在权重的确定上采用熵权系数,以此为基础构建大学生体质健康水平综合评价体系,客观反映了大学生体质健康水平及个体间的差异.     

微量元素与儿童健康

论述了常见微量元素与儿童健康的关系，并简要地介绍了部分常见微量元素对人体的作用。提出了一些微量元素缺少或过量的药物治疗方法。